Fluorinate polyacrylic acid and its use as a potential adjuvant field

This study describes a polymer potentially used as vaccine adjuvant. We first synthesized novel polyacrylic acid modified by perfluorinated butanol—a bioactive compound that is biocompatible. The main aim was to functionalize the fluorine. functionalization could offer permanent graft an esterification reaction. chemical structure of has been characterized hydrogen nuclear magnetic resonance spectrum (1H-NMR) and fourier transform infrared (FT-IR). Thermal analysis showed reaction successful on acid. Viscosity testing viscosity sample aqueous solution increases along with esterification. surface tension also tested. results show markedly decreased when Finally, interaction these materials macrophages tested cell test. Results performed better improve activation effect than pure in 1L-1β.